Nation/World

New flu vaccine may offer quicker fix

SAN FRANCISCO – The flu vaccine-making system that serves as the best available protection against a pandemic relies on millions of chicken eggs, takes nine months to produce each year’s flu shots and has changed little since the 18th century.

This creaky system poses a big problem if a new, deadly strain emerges once the annual and inflexible production process begins.

Several biotechnology companies are at work on a new and quicker way of making a flu vaccine they hope can replace one that requires people to be inoculated with the entire influenza virus. Their technique: extract just a few genes from the virus and inject it into people.

The nascent technology, called DNA vaccines, is a form of gene therapy that proponents argue is the best way to overhaul a 50-year-old vaccine manufacturing system.

In the meantime, most government and big pharmaceutical research funds are still pouring resources into the egg-based process.

The U.S. government awarded Chiron Corp. $62.5 million last week to produce shots that protect against the bird flu strain. Last month, Sanofi-Pasteur received $100 million for a similar government project. Both companies still use eggs to manufacture vaccines.

Chiron, the nation’s second-largest vaccine supplier, also plans to spend more than $100 million updating its beleaguered egg-based factory in Liverpool, England.

Most government and big pharma efforts on the influenza vaccine front are doing one thing new: They’re seeking to shave a few weeks off the process by trading in the chicken eggs for mammal cells, the standard brewing technique used to make biotechnology drugs.

The old and new vaccine-making techniques all rely, of course, on the same principle: tricking the body to create natural defenses against disease.

Under the current system, the three flu bug versions that are expected to be the coming season’s most prevalent strains are injected in chicken eggs to multiply before undergoing a long process of inactivation, sterilization and packaging.

Flu also is the only vaccine made fresh every year because the virus mutates so rapidly. Because vaccines are biological products, not chemicals, they can’t be cranked out quickly in times of need.

The gene jockeys touting DNA vaccines say they are getting close to making vaccines with less effort. They claim they can soon produce flu vaccines in less than three months that would allow for injecting people with key bits of a flu’s DNA.

If a flu were to mutate into something unexpected, researchers say they can simply grab a gene from the new strain and gin up more vaccine. Best of all, they argue, their technology knocks drug makers out of the chicken wrangling business, the biggest limitation of the current system.

“We are badly in need of flexible vaccines programs,” said Erik Henchal, a former commander of the U.S. Army Medical Research Institute of Infectious Diseases, which aims to keep U.S. troops healthy and combat biowarfare threats.

Henchal said the current production system requires researchers to handle live influenza viruses, a dangerous procedure that DNA vaccines promise to eliminate if successful.

DNA vaccines were first introduced about 10 years ago as a possible treatment for a variety of diseases, from AIDS to cancer. They worked great in mice, but largely failed to work in humans because the injected genes did not find their way into the cells.

Vijay Samant, chief executive of Vical Inc. in San Diego, said those initial problems have been overcome and his company is testing DNA vaccines in cancer and AIDS patients to battle those diseases.

Canadian fish farmers are using the firm’s technology to inoculate salmon against a deadly virus that makes them bleed from their gills.

In Oxford, England, the tiny biotechnology company PowderMed tested its DNA vaccine for a common flu strain this summer in 12 people to ensure the technology was safe. It was the first such human test of DNA vaccine for flu and the company said it was successful enough to begin new trials with more people.

It’s also planning a human trial next year to test its DNA vaccine against the bird flu, though any mass-produced product is still several years away.

PowderMed overcame the problem of getting the flu’s DNA to cells that need to be tricked into thinking the body has been infected with flu by coating the flu’s genetic material with microscopic gold particles and shooting it into skin cells at the speed of sound, said PowderMed’s chief scientist Dr. John Beadle.

“I think people are looking at older and more established technology as the safe bet right now,” Beadle said. “And that this stuff is too far out and risky.”

PowderMed was spun out of Powderject Inc. after that company was purchased by Chiron for $858 million in 2003. Powderject and its egg-based factory were a major U.S. flu shot provider.

But, last year, British health officials barred the old Powderject factory from delivering 48 million flu shots to the United States because of contamination concerns.

The debacle has cost Chiron more than $200 million in lost sales and related expenses.



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