April 3, 2007 in Nation/World

Mammogram advice challenged

Rob Stein Washington Post
 

Fast facts

Breast cancer strikes more than 212,000 U.S. women each year and kills more than 40,000.

WASHINGTON – The nation’s largest medical specialty group is challenging the widely accepted recommendation that women should routinely undergo mammograms in their 40s, saying the risks of the breast exams may outweigh the benefit for many women.

Reopening a long-running debate, the American College of Physicians, which represents 120,000 internists, plans to issue new guidelines today that instead urge women in their 40s to consult with their doctors individually about whether to get the breast X-rays.

The group based its recommendations on a comprehensive review of research on mammography that concluded the benefit is less clear for women in their 40s than for those 50 and older, and that screening carries significant risks, including exposure to radiation and unnecessary biopsies, surgery and chemotherapy.

The guidelines conflict with long-standing recommendations from several other leading medical groups, including the American Cancer Society and National Cancer Institute.

“We agree that mammography can save lives,” said Douglas Owens of Stanford University, chairman of the committee that wrote the guidelines being published in the Annals of Internal Medicine. “But there are also potential harms. We don’t think the evidence supports a blanket recommendation.”

The new guidelines elicited mixed reactions from breast cancer advocates, doctors and researchers. Some condemned them, saying mammograms clearly help catch tumors at their earliest, most treatable stage, reducing the death toll from the common malignancy. Breast cancer tends to be especially deadly when it strikes women in their 40s, they noted.

“The danger here is that some women will elect not to get screened,” said Robert A. Smith, director of cancer screening at the American Cancer Society. “Mammography is the single most effective way of finding breast cancer early, and when we find breast cancer early women have the greatest chance of successful treatment.”

But others said the recommendations represent a more nuanced approach that better reflects what is known about the benefits and drawbacks of mammography.

“I think it’s right on target,” said Russell Harris of the U.S. Preventive Services Task Force, which issues the federal government’s official recommendations on preventive medicine. “I would like to see more women stop and think about the decision.”

The new guidelines come less than a week after the Cancer Society issued new guidelines that, for the first time, recommend that women at greatest risk for breast cancer also undergo annual MRI exams. That statement triggered a similar debate over the risks and benefits of aggressive screening.

Owens acknowledged that the conflicting recommendations may confuse some women, but said the panel concluded it was important to present women with a realistic assessment.

“All we’re saying is that women should be informed about the risks and benefits so they can make a decision based on all the facts,” Owens said.

Breast cancer strikes more than 212,000 U.S. women each year and kills more than 40,000, making it the most common cancer in women after skin cancer and second leading cancer killer after lung cancer.

Since the 1990s, the Cancer Society and other groups have been recommending mammograms every year or two for women beginning at age 40, and they credit the exams with helping reduce the death rate from the widely feared disease. But the recommendations have long been mired in controversy, with some researchers saying the benefit in that age group is marginal and subjects thousands to overdiagnosis and overtreatment.

To re-examine the issue, the College of Physicians asked a six-member panel of experts to develop new guidelines based on a comprehensive review of the scientific literature between 1966 and 2005. Unlike previous reviews, the analysis of 117 studies included a thorough evaluation of the negative consequences of mammograms, the group said.

The panel concluded that routine mammography screening might reduce the breast cancer death rate by about 15 percent, but the data are so unclear that it “could be larger or nearly zero.” In contrast, mammograms cut the death rate by a clear 22 percent for women age 50 and older, the group said.

That possible “modest” benefit for women in their 40s needs to be weighed against the risks, the panel concluded. As many as half of all women undergoing annual mammograms throughout their 40s may have a false alarm, which often leads to repeated exams and biopsies, causing anxiety, pain and possibly disfigurement.

Mammograms tend to detect a very early form of breast cancer known as ductal carcinoma in-situ, or DCIS, which may never become life-threatening, the panel noted. Nevertheless, a DCIS diagnosis leads to lumpectomies, mastectomies, radiation and chemotherapy. Mammograms can also miss some cancers, falsely reassuring women, the panel noted.


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