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Man with skin cancer saved by new treatment

Thu., June 19, 2008

ATLANTA – An Oregon man, given less than a year to live, had a complete remission of advanced deadly skin cancer after an experimental treatment that revved up his immune system to fight the tumors.

The 52-year-old patient’s dramatic turnaround was the only success in a small study, leading doctors to be cautious in their enthusiasm. However, the treatment reported in today’s issue of the New England Journal of Medicine is being counted as the latest in a small series of successes involving immune-priming treatments against deadly skin cancers.

Still, the immune-priming experiments have yet to yield a consistent therapy. Even researchers who worked on the experiment involving nine patients and just one success are quick to couch the result. “This is only one patient,” said study co-author Dr. Cassian Yee of the Fred Hutchinson Cancer Research Center in Seattle.

And two years after his remarkable recovery, the patient fell out of contact with researchers and scientists do not know his current condition. The man, who lives in a small town in Oregon, has declined media interviews, Yee said.

Melanoma is a cancer in the skin cells that make pigments and cause skin to tan, as part of the body’s attempt to protect itself from ultraviolet radiation in sunlight. Cancer begins when radiation overloads and damages the cells, causing mutations.

When caught early, melanomas can be easily treated by surgically removing the cancerous patch of skin. But “once it has spread, basically nothing works,” said Dr. Darrell Rigel, a researcher at the New York University Cancer Institute.

Recently, however, scientists began thinking they might have another option: helping the body’s immune system.

Doctors had long thought that immune system cells, which so effectively attack foreign threats like viruses, were giving a pass to cancer cells. The theory was that because cancers cells are generated by the body, the immune system perceived them as part of the body.

But about 20 years ago, some scientists discovered that immune cells could latch onto and attack skin cancers.

“There’s a long history behind all of this,” said Dr. Steven Rosenberg of the National Cancer Institute.

In recent experiments, Rosenberg and other researchers have focused on souping up a certain kind of immune system cell – the “killer T cells” that envelop and kill foreign agents.

The new research took a different approach. The Hutchinson center scientists focused instead on specific helper T cells that are adept at locking onto a cancer cell and guiding the killer cells to their target.


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