March 20, 2008 in Nation/World

Old blood may raise surgery risks

Mike Stobbe Associated Press
 

ATLANTA – Heart surgery patients were more likely to die or suffer problems if they received transfusions of blood that is more than two weeks old rather than fresher blood, according to a new study that adds to the debate about the shelf life of blood.

Although not the final word, the study underscores concerns that blood deteriorates with age and that rules allowing blood to be stored for six weeks may pose a safety risk, at least for certain patients.

The findings bolster the argument of those who believe that older blood should be avoided, Dr. John Adamson of the University of California, San Diego, wrote in an editorial accompanying the study in this week’s New England Journal of Medicine.

“However, the results of this study will not settle the debate” because the patients studied were not representative of all transfusion recipients, he added.

The report was limited to heart surgery patients, but similar results have been shown in smaller studies that looked at other types of patients.

The Food and Drug Administration’s six-week rule allows blood centers to endure shortages in donations and to maintain supplies of rare blood types.

The study’s lead author, Dr. Colleen Gorman Koch of the Cleveland Clinic, did not call for an immediate change to the FDA rule. But Koch said a more rigorous study is already under way that could carry the scientific weight to persuade the FDA to reconsider its policy.

In a statement, the FDA said the findings were “provocative” but that more rigorous testing would be needed before it reviews the policy. Still, the agency said, doctors may wish to consider the report in making treatment decisions.

It’s not clear exactly why blood stored for longer periods is riskier. Some researchers say stored blood becomes depleted of oxygen-carrying chemicals. Red blood cells also become more rigid in storage, impeding their flow through the body.

Researchers examined the records of 6,000 patients who were given blood transfusions during heart-bypass or heart-valve surgery. All of the patients were treated at the Cleveland Clinic from June 30, 1998, through Jan. 30, 2006.

A little less than half of the patients received blood that had been stored for 14 days or less, and a little more than half got blood that was older. The amount of blood given to patients in both groups was similar.

The study found that the one-year survival rate was 89 percent for those who got older blood, but nearly 93 percent for patients who got fresher blood.

Complication rates were higher in the older blood group, with higher proportions of those patients suffering kidney failure, blood infections or multiple organ failure, or needing ventilator care more than 72 hours after surgery.

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