August 22, 2013 in Nation/World

Ebola drug effective on monkeys

Treatment helps even after symptoms appear
Eryn Brown Los Angeles Times
 
A dangerous disease

Ebola is a viral hemorrhagic fever and one of the most virulent diseases known to humankind.

The Ebola virus was first identified in the western equatorial province of Sudan and in a nearby region of Zaire (now Democratic Republic of the Congo) in 1976 after significant epidemics in southern Sudan and northern Zaire.

The Ebola virus is transmitted by direct contact with the blood, body fluids and tissues of infected persons. Transmission of the Ebola virus has also occurred by handling sick or dead infected wild animals (chimpanzees, gorillas, monkeys, forest antelope, fruit bats).

World Health Organization

An experimental Ebola treatment – produced in the leaves of specially engineered tobacco plants – saved the lives of three monkeys who were already showing symptoms of the illness, according to a report published Wednesday in the journal Science Translational Medicine.

The report suggests that it may be possible someday to treat people who show up in medical facilities already sickened with the horrific disease.

While scientists already knew various Ebola treatments administered before symptoms appeared were effective in animals such as monkeys, they hadn’t yet shown such treatments worked once fevers and other symptoms had set in – a key capability in real-world outbreak situations, said study co-author and virologist Gene Olinger of the Army Medical Research Institute of Infectious Diseases at Fort Detrick, Md.

“We’ve pushed the opportunity to treat people to the point where they walk in and say, ‘I have a fever,’ ” he said. “A lot of folks in the field would have thought protecting an animal at the time of fever and viremia is too late to have a clinical benefit.”

Working in a high-security laboratory, the team tested the drug, known as MB-003, on seven rhesus macaques that were deliberately infected with Ebola – an RNA virus that causes fevers, sore throat, diarrhea, vomiting, and internal and external bleeding. The illness is often fatal.

Study first author James Pettitt, also of the Army medical research institute, said the goal was to “simulate what would happen in an outbreak,” so the team waited until the monkeys: a) tested positive for Ebola; and b) had fevers before initiating treatment.

The team administered doses of MB-003 intravenously once every three days. Four of the monkeys died of Ebola, but three survived. While 43 percent success may seem underwhelming, it’s a result that is statistically significant, the researchers said. For experimental purposes, they added, they had to stick to the once-every-three-days regimen. But Pettitt said it’s likely that if MB-003 were being administered in the field, health workers would increase the dosage and frequency of treatment once patients fell ill.

“We think we’ll get better results,” he said.

The antibodies in MB-003 are manufactured in specially engineered tobacco plants, grown in a greenhouse facility in Kentucky, Olinger said. The process is quick, currently allowing production of more than a hundred doses of the drug in a seven-day cycle. At the moment, it’s also cheaper than the cell-based manufacturing methods usually used to produce such drugs.

The next step for MB-003 will be for researchers to try to improve the drug’s efficacy by incorporating additional antibodies identified by another research team. Scientists may also apply to begin drug safety trials in humans, Olinger said.


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