BOSTON – What happens to fish that swim in waters tainted by traces of drugs that people take? When it’s an anti-anxiety drug, they become hyper, anti-social and aggressive, a study found. They even get the munchies.
It may sound funny, but it could threaten the fish population and upset the delicate dynamics of the marine environment, scientists say.
The findings, published online Thursday in the journal Science, add to the mounting evidence that minuscule amounts of medicines in rivers and streams can alter the biology and behavior of fish and other marine animals.
“I think people are starting to understand that pharmaceuticals are environmental contaminants,” said Dana Kolpin, a researcher for the U.S. Geological Survey who is familiar with the study.
Calling their results alarming, the Swedish researchers who did the study suspect the little drugged fish could become easier targets for bigger fish because they are more likely to venture alone into unfamiliar places.
“We know that in a predator-prey relation, increased boldness and activity combined with decreased sociality … means you’re going to be somebody’s lunch quite soon,” said Gregory Moller, a toxicologist at the University of Idaho and Washington State University. “It removes the natural balance.”
Researchers around the world have been taking a close look at the effects of pharmaceuticals in extremely low concentrations, measured in parts per billion. Such drugs have turned up in waterways in Europe, the U.S. and elsewhere over the past decade.
They come mostly from humans and farm animals; the drugs pass through their bodies in unmetabolized form. These drug traces are then piped to water treatment plants, which are not designed to remove them from the cleaned water that flows back into streams and rivers.
The research team at Sweden’s Umea University used minute concentrations of 2 parts per billion of the anti-anxiety drug oxazepam, similar to concentrations found in real waters. The drug belongs to a widely used class of medicines known as benzodiazepines that includes Valium and Librium.
The team put young wild European perch into an aquarium, exposed them to these highly diluted drugs and then carefully measured feeding, schooling, movement and hiding behavior. They found that drug-exposed fish moved more, fed more aggressively, hid less and tended to school less than unexposed fish. On average, the drugged fish were more than twice as active as the others, researcher Micael Jonsson said. The effects were more pronounced at higher drug concentrations.
“Our first thought is, this is like a person diagnosed with ADHD,” said Jonsson, referring to attention deficit-hyperactivity disorder. “They become asocial and more active than they should be.”
Tomas Brodin, another member of the research team, called the drug’s environmental impact a global problem. “We find these concentrations or close to them all over the world, and it’s quite possible or even probable that these behavioral effects are taking place as we speak,” he said Thursday in Boston at the annual meeting of the American Association for the Advancement of Science.
It is not clear exactly how long-term drug exposure, beyond the seven days in this study, would affect real fish in real rivers and streams. The Swedish researchers argue that the drug-induced changes could jeopardize populations of this sport and commercial fish, which lives in both fresh and brackish water.
Water toxins specialist Anne McElroy of Stony Brook University in New York agreed: “These lower chronic exposures that may alter things like animals’ mating behavior or its ability to catch food or its ability to avoid being eaten – over time, that could really affect a population.”
Another possibility, the researchers said, is that more aggressive feeding by the perch on zooplankton could reduce the numbers of these tiny creatures. Since zooplankton feed on algae, a drop in their numbers could allow algae to grow unchecked. That, in turn, could choke other marine life.