Andy Murray ousted from U.S. Open in 4th round by Kevin Anderson

NEW YORK – Andy Murray watched a 130 mph ace zoom by to create a two-set deficit at the U.S. Open, and then sat in his changeover chair and cursed at himself, over and over and over.

A little later, Murray cracked his racket against the court once, breaking the frame, and went to the sideline and mangled his equipment even more, before meandering over to hand it to someone in the stands.

Often able to spur himself by letting out some anger, the two-time Grand Slam title winner only briefly managed to get into this match. The third-seeded Murray lost before the quarterfinals at a major for the first time since 2010, beaten 7-6 (5), 6-3, 6-7 (2), 7-6 (0) by 15th-seeded Kevin Anderson of South Africa in the fourth round at Flushing Meadows on Monday.

For the 6-foot-8 Anderson, known mainly for a booming serve but terrific off the ground in this 4-hour, 18-minute victory, it marked a real breakthrough: He entered with an 0-7 record in fourth-round matches at majors, including when he had a two-set lead against Novak Djokovic at Wimbledon.

This time, Anderson held it together with the help of 25 aces and 81 total winners.

Federer stops Isner

Roger Federer shut out John Isner in a tiebreaker – something that had never happened to the big-serving, 6-foot-10 American in an official, tour-level match – and won their fourth-round match 7-6 (0), 7-6 (6), 7-5.

Federer broke in the last game, ending Isner’s streak of 110 consecutive service holds at Flushing Meadows over the last two years.

Federer has not dropped a set on the way to a quarterfinal against No. 12 Richard Gasquet, who got past No. 6 Tomas Berdych 2-6, 6-3, 6-4, 6-1.

Veterans advance

Victoria Azarenka and Stan Wawrinka, both two-time Grand Slam champions, make trips to the U.S. Open quarterfinals an annual affair.

Their experience showed against opponents who don’t know how it feels to go that far at a major.

Azarenka, whose ranking is down to 20th after two injury-plagued seasons, is starting to look like the player who took Serena Williams to three sets in the final at Flushing Meadows in 2012 and ’13. On Monday, she won 6-3, 6-4 over 46th-ranked American Varvara Lepchenko, who had reached her first U.S. Open round of 16.

Donald Young had come from behind in his three previous matches, twice rallying from down two sets, but Wawrinka’s power and poise never gave him much of a chance to do it again no matter how loud the Arthur Ashe Stadium crowd roared. The fifth-seeded Wawrinka won 6-4, 1-6, 6-3, 6-4, controlling the final two sets behind his big serve.

Halep outlasts Lisicki

With both players limping around by the third set, second-seeded Simona Halep outlasted Sabine Lisicki to reach her first U.S. Open quarterfinal.

Halep, who had her left thigh wrapped after wasting two set points in the first, won 6-7 (6), 7-5, 6-2 in 2 hours, 38 minutes on a hot afternoon.

Nadal’s grandfather dies

Mallorca’s regional government says the grandfather of Spanish tennis star Rafael Nadal has died. He was 85.

The elder Rafael Nadal became the patriarch of a renowned sporting family as his five children included soccer player Miguel Nadal, who played for Spain at three World Cups, and Toni Nadal, who has coached the younger Rafael throughout his tennis career.