Top 25 roundup: Old Dominion stuns 13th-ranked Virginia Tech 49-35

Blake LaRussa came off the bench to throw for 495 yards and four touchdowns to lead Old Dominion to a 49-35 upset of No. 13 Virginia Tech on Saturday in Norfolk, Virginia, in the Hokies’ first game at the cross-state school that restarted its football program in 2009.

LaRussa entered on ODU’s second series and completed 30 of 49 and ran for a score to lead the 28 1/2-point underdog Monarchs (1-3) to a stunning win over the Hokies (2-1) from the Atlantic Coast Conference.

Jeremy Cox’s 40-yard touchdown run with 1:34 remaining sealed the biggest win in program history. After the game, the ODU faithful stormed the field.

(1) Alabama 45, (22) Texas A&M 23: Tua Tagovailoa passed for 387 yards and four touchdowns and ran for another score to lead the Crimson Tide past the Aggies in Tuscaloosa, Alabama.

(2) Georgia 43, Missouri 29: Jake Fromm threw three touchdown passes and the Bulldogs had a defensive touchdown and returned a blocked punt for a score in a win over the Tigers in Columbia, Missouri.

(3) Clemson 49, Georgia Tech 21: Freshman Trevor Lawrence took a leading role in the Tigers’ quarterback rotation, coming off the bench to throw four touchdown passes against the Yellow Jackets in Atlanta.

(4) Ohio State 42, Tulane 6: Dwayne Haskins Jr. threw for 304 yards and five touchdowns in the first half and the Buckeyes routed the Green Wave in Columbus, Ohio, in coach Urban Meyer’s return to the sideline following a three-game suspension.

(5) Oklahoma 28, Army 21 (OT): Kyler Murray threw a 10-yard touchdown pass to CeeDee Lamb in overtime, and Parnell Motley intercepted Kelvin Hopkins’ fourth-down pass to help the Sooners escaped with a victory over the Black Knights in Norman, Oklahoma.

(6) LSU 38, Louisiana Tech 21: Nick Brossette scored three touchdowns, Clyde Edwards-Helaire rushed for a career-high 136 yards and two TDs, and the Tigers topped the Bulldogs in Baton Rouge, Louisiana.

(8) Notre Dame 56, Wake Forest 27: Ian Book rushed for three touchdowns and threw for two more for the Fighting Irish in a rout of the Demon Deacons in Winston-Salem, North Carolina.

(9) Auburn 34, Arkansas 3: Noah Igbinoghene scored on a 96-yard kickoff return, and a partially blocked punt by Jordyn Peters set up another touchdown as big plays on special teams helped the Tigers beat the Razorbacks in Auburn, Alabama.

(12) West Virginia 35, Kansas State 6: Will Grier threw five touchdown passes for the fifth time in his career and the Mountaineers shook off a sloppy start in the Big 12 opener against the Wildcats in Morgantown, West Virginia.

Kentucky 28, (14) Mississippi State 7: Benny Snell Jr. rushed for four touchdowns to break a Kentucky career record, including two in the fourth quarter, and the Wildcats held the Bulldogs to 56 yards rushing in Lexington, Kentucky.

Texas Tech 41, (15) Oklahoma State 17: Alan Bowman threw for 397 yards and two touchdowns and the Red Raiders ended a nine-game losing streak to the Coyboys with a win in Stillwater, Oklahoma.

Texas 31, (17) TCU 16: Sam Ehlinger passed for two touchdowns and ran for a score, all in the second half, and the Longhorns ended a four-game losing streak to the Horned Frogs in Austin, Texas.

(18) Wisconsin 28, Iowa 17: Alex Hornibrook threw a 17-yard TD pass to A.J. Taylor with 57 seconds left and the Badgers bounced back from last week’s loss by rallying past the Hawkeyes in Iowa City, Iowa.

(19) Michigan 56, Nebraska 10: Karan Higdon ran for 136 yards and a touchdown in the first half for the Wolverines in Ann Arbor, Michigan, and the Cornhuskers stumbled to their worst start since 1945.

(21) Miami 31, FIU 17: N’Kosi Perry came off the bench to throw three touchdown passes, and the Hurricanes’ defense was airtight for most of the day against the Golden Panthers in Miami Gardens, Florida.

Purdue 30, (23) Boston College 13: Rondale Moore caught two touchdown passes and the Boilermakers picked off four Eagles’ passes in West Lafayette, Indiana.

(24) Michigan State 35, Indiana 21: Brian Lewerke threw two touchdown passes, had his first career catch and made the perfect pitch to kicker Matt Coghlin for a 6-yard scoring run to lead the Spartans past the Hoosiers in Bloomington, Indiana.

(25) BYU 30, McNeese State 3: Freshman Lopini Katoa ran for two touchdowns, Skyler Southam kicked three field goals and the Cougars took advantage of the Cowboys’ second-quarter mistakes in Provo, Utah.