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Breaking Nicotine’s Powerful Draw

Low-nicotine VLN cigarettes are seen for sale at a Circle K store in Chicago on June 21. Millions of smokers could be forced to confront the agony of nicotine withdrawal as the FDA weighs calling for a drastic reduction in the addictive lure of cigarettes.  (Taylor Glascock/The New York Times)
Low-nicotine VLN cigarettes are seen for sale at a Circle K store in Chicago on June 21. Millions of smokers could be forced to confront the agony of nicotine withdrawal as the FDA weighs calling for a drastic reduction in the addictive lure of cigarettes. (Taylor Glascock/The New York Times)
By Andrew Jacobs New York Times

At some point in the next few years, the 30 million smokers in the United States could wake up one day to find that cigarettes sold at gas stations, convenience stores and smoke shops contain such minuscule amounts of nicotine that they cannot not get their usual fix when lighting up.

Would the smokers be plunged into the agonizing throes of nicotine withdrawal and seek out their favorite, full-nicotine brand on illicit markets, or would they turn to vaping, nicotine gum and other less harmful ways to get that angst-soothing rush?

Such scenarios inched closer to the realm of possibility in June, when the Food and Drug Administration said that it would move toward slashing nicotine levels in cigarettes in an effort to reduce the health effects of an addiction that claims 480,000 lives a year.

The agency set next May as its timetable for introducing a fully developed proposal. But many experts hope regulators will champion an immediate 95% reduction in nicotine levels – the amount federally funded studies have determined is most effective for helping smokers kick the habit.

It could be years before any new policy takes effect, if it survives opposition from the tobacco industry. Even so, health experts say any effort to decrease nicotine in cigarettes to nonaddictive levels would be a radical experiment, one that has never been carried out by any other country.

The science of nicotine addiction has come a long way since 1964, when a U.S. surgeon general report first linked smoking to cancer and heart disease, although it would take another two decades for the mechanics of nicotine dependence to be understood and widely accepted.

Tobacco contains more than 7,000 chemicals, many of them harmful when burned and inhaled, but it is nicotine that keeps smokers coming back for more. Nicotine stimulates a surge of adrenaline in the brain while indirectly producing a flood of dopamine, the chemical that promotes feelings of contentment and relaxation. The effects, however, are short-lived, which is why heavy smokers need a fresh injection a dozen or more times a day.

Eric Donny, a tobacco expert at Wake Forest University School of Medicine who has conducted experiments with low-nicotine cigarettes, said many scientists had come to embrace a 95% reduction in nicotine levels as ideal for helping study subjects smoke less. Anything higher, he said, can encourage participants to engage in so-called compensatory smoking – inhaling more deeply or smoking more frequently.

The studies he and other scientists have run recently used genetically modified tobacco bred to express less nicotine; bringing nicotine down to zero is not an option under the Tobacco Control Act, a 2009 law that gave the FDA the power to regulate the manufacture and marketing of tobacco.

“When you get the nicotine in tobacco low enough, you just can’t get enough nicotine to maintain the dependence,” Donny said. “Smoking more creates adverse effects, like nausea, because the lungs can only handle so much of a burned substance.”

But even as tobacco control researchers cheered the FDA announcement, they acknowledged that any move to lower nicotine in cigarettes would be enormously challenging for inveterate smokers – even among the 70% who have said they would like to stop. As it is, fewer than one in 10 adults who try to quit smoking succeed, a reflection of nicotine’s addictive prowess and the limitations of nicotine replacement therapy.

Dr. Nora Volkow, director of the National Institute on Drug Abuse, expressed confidence in the studies that backed an immediate cut in nicotine levels versus a gradual tapering. But she said that scientists and regulators still needed to address the welter of unforeseen consequences that could prove disruptive to determined smokers and could fuel the creation of underground markets for full-nicotine cigarettes. “You cannot completely predict outcomes based on a clinical randomized study,” she said. “Biology and life are not so precise.”

Some scientists have urged caution for any plan that would drastically cut nicotine levels in one fell swoop, warning that the existing research on low-nicotine cigarettes is imperfect, given the high number of study participants who cheat. The skeptics, among them tobacco company executives, warn that banning conventional cigarettes would drive determined smokers to seek imports from Mexico and Canada. They also argue that some smokers, including teenagers, could develop a habit that pairs vaping or nicotine gum with low-nicotine cigarettes, which are just as carcinogenic as traditional cigarettes.

Lynn T. Kozlowski, a tobacco researcher at the University at Buffalo who has contributed to four surgeon general reports on smoking since 1981, said that nicotine was a highly addictive drug, with a stranglehold on users that could rival cocaine and heroin, and that the FDA needed to consider how a sweeping decrease of nicotine in cigarettes would affect smoker behavior.

“What scares me is a national experiment with very-low-nicotine cigarettes that is done without some testing in the real world,” he said. The studies many experts cite when promoting a 95% drop in nicotine levels relied upon paid participants, he noted, adding that some of them secretly smoked their own brands at the same time that researchers were plying them with low-nicotine cigarettes.

In interviews, smokers who had heard about the FDA’s announcement said they were conflicted by the prospect of being forced to abandon their addiction, despite knowing full well that it damaged their health and would likely shorten their life span.

Mike Harrigan, an options trader who was taking a smoking break outside the Chicago Board of Trade, said he feared he might actually end up smoking more if cigarettes contained significantly lower amounts of nicotine. “It may help newer smokers, but it will hurt people who are used to a certain level of nicotine,” said Harrigan, 55, who has been a pack-a-day smoker for three decades.

Dr. Judith Prochaska, an addiction specialist at Stanford University who runs a smoking cessation clinic for patients with cancer and their families, said lighting up during a stressful phone call, while sipping a cocktail or following a heavy meal created a powerful memory that conditioned the mind into associating a cigarette with the stimulation or succor that it delivered via the rush of nicotine.

“All these everyday behaviors cue your brain that nicotine is coming,” she said. “It’s basically the Pavlovian dog effect but conditioned here with a highly addictive drug.”

Over time, the dependency deepens. Regular smoking promotes the formation of additional dopamine receptors – sometimes millions more. When a smoker goes cold turkey, those unrequited receptors prompt the anxiety, irritability and depression that can make nicotine withdrawal so hard to bear.

Nicotine patches, gum and vapes can help to satisfy some of the cravings, but they cannot replace the rituals of having a cigarette: the retreat outside with a co-conspirator, the crinkling of cellophane and foil as you open a new pack, the heady buzz of that first drag.

This article originally appeared in The New York Times.

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