Gonzaga finished off the first half by scoring 13 of the last 14 points to open up a 48-27 lead over Santa Clara at the break.
The Zags took the lead for good on Austin Daye's two free throws with 15:47 left. The margin eventually grew to 10 on Steven Gray's two free throws. Gonzaga led 35-26 when Daye connected on a 14-foot baseline jumper with 3:08 remaining, triggering 13 consecutive points. Jeremy Pargo, who had a big half with 14 points, tipped a loose ball away from the Broncos and chased it down in the corner. His 3-pointer made it 40-26 and he added another 3-pointer seconds later.
Matt Bouldin's 3-pointer and another Daye jumper hiked GU's lead to 48-26 before John Bryant made one of two free throws with 24.4 seconds left.
Pargo made 5 of 6 shots en route to 14 points. Daye had 13 points and Micah Downs added eight. The Zags had a big edge at the free-throw line, making 11 of 13 to Santa Clara's 4 of 7.
Kevin Foster led Santa Clara with 12 points. Bryant, the conference player of the year, had three points and five rebounds.