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People’s Pharmacy: Is acetaminophen or ibuprofen better for fever?

UPDATED: Wed., Nov. 25, 2020

Tablets of ibuprofen are pictured in New York on Nov. 2, 2017.  (Patrick Sison/Associated Press)
Tablets of ibuprofen are pictured in New York on Nov. 2, 2017. (Patrick Sison/Associated Press)
By Joe Graedon, M.S., </p><p>and Teresa Graedon, Ph.D. King Features Syndicate

Q. My dad was a pharmacist, yet as a kid I don’t recall taking a lot of medicines, like cough syrup. We did use Vicks VapoRub and take vitamin C for colds.

I’ve seen debates on giving ibuprofen or Tylenol to reduce fever. Sometimes doctors leave comments on your website advising people to let a fever run its course. Does that hold for everyone or just for adults? A lot of parents I know give their young children medicines to knock down every fever.

A. A fever is often the body’s response to infection. That’s why many physicians now believe that a mild fever does not require medication. Parents should measure a child’s temperature and check in with a pediatrician if it goes over 102 degrees.

A recent study in JAMA Network Open (Oct. 30) analyzed trials of acetaminophen compared with ibuprofen to treat fever in kids younger than 2. The authors concluded that both drugs are relatively safe and that ibuprofen is slightly more effective for fever and pain.

Q. I have been taking statins for maybe 20 years. The past four years, it’s been atorvastatin, with an increased dose (40 mg) over the past two.

Recently, my doctor diagnosed me with peripheral neuropathy. I am not diabetic nor deficient in any vitamin, including vitamin B. Is it possible that atorvastatin is the cause of my neuropathy?

A. Nerve damage leading to numbness, pain or weakness remains a controversial statin side effect. The official prescribing information for atorvastatin (Lipitor) lists peripheral neuropathy under the category “postmarketing experience.”

In other words, this symptom was not detected in the original clinical trials used for Food and Drug Administration approval. It was reported to the agency by patients and health care providers voluntarily, which is why the FDA says it could not “establish a causal relationship to drug exposure.”

Researchers have noted, however, that statins have been linked to neuropathy (American Journal of Cardiovascular Drugs, Vol. 8, No. 6, 2008). Cardiologists maintain that there is “no convincing evidence for a causal relationship.” On the other hand, neurologists suspect that statins increase the risk for peripheral neuropathy (Pain and Therapy, Feb. 4).

Q. I’m a 49-year-old male who leads a healthy life. I saw my doctor to address a lack of energy and feelings of depression. Six months ago, I started following a vegan diet. I consider myself well-informed and felt I was eating a balanced, healthy diet.

The blood results showed everything was fine except for thyroid markers. I was immediately put on a low dose of levothyroxine and sent for a second round of blood tests.

My levothyroxine dosage has been raised, but I’m feeling absolutely no different from before. I read that iodine deficiency could contribute to thyroid problems.

Could six months of veganism have caused this situation?

A. German scientists have studied nutritional differences between vegans and nonvegans (Deutsches Arzteblatt, Aug. 31). Somewhat to their surprise, they found that most vegans had adequate vitamin B12 levels, although they consumed very little in their diet. On the other hand, approximately one-third were deficient in iodine.

This mineral is critical for healthy thyroid function. You can learn more about it in our eGuide to Thyroid Hormones. This online resource is available in the Health eGuides section of

In their column, Joe and Teresa Graedon answer letters from readers. Write to them in care of King Features, 628 Virginia Drive, Orlando, FL 32803, or email them via their website Their newest book is “Top Screwups Doctors Make and How to Avoid Them.”

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