Folate levels dropping in young women

ATLANTA – Blood levels of folate in young women are dropping, a disturbing development that could lead to increased birth defects and may be due to low-carb diets or the popularity of unfortified whole-grain breads.

Government health officials could only speculate on the reasons but called the backslide in this important B vitamin disturbing.

It’s not clear how the decline in folate levels has affected newborns, but preliminary data suggest the dramatic declines in neural tube defects seen in the late 1990s may have leveled off by 2004, said officials with the U.S. Centers for Disease Control and Prevention.

“This is a cause of substantial concern,” said Dr. Nancy Green, medical director for the March of Dimes, which campaigns for birth defects prevention.

Folate is a naturally occurring B vitamin. An artificial version, which is more easily metabolized by the body, is folic acid.

Years ago, scientists concluded that folate deficiencies contributed to the occurrence of serious birth defects of the spine and brain, known as neural tube defects.

So the government has long urged women to eat cereals and breads fortified with folic acid to help prevent birth defects. By the late 1990s, the fortification campaigns were succeeding: Folate levels increased, and neural tube defects dropped by as many as 1,000 a year.

But a CDC study released Thursday found an 8 percent to 16 percent decline in folate levels in U.S. women of childbearing age, according to large blood-drawing surveys done between 1999 and 2004.

It was the first time such a decline has been seen since the start of government health campaigns urging women to make sure they get enough folic acid.

The decline was most pronounced in white women, although black women continue to be the racial group with the least folate in their blood, health officials said.

The study was based on a regular national survey that involves interviews, physical examinations and blood tests. It measured the blood of about 4,500 women, ages 15 to 44, between 1999 and 2004.

It’s being published this week in a CDC publication, Morbidity and Mortality Weekly Report.

It’s not clear why blood folate levels dropped in this decade, but there are several possible explanations, experts said.

Increasing obesity rates among young women may be a factor.

Diet trends may have been be another factor, said Dr. Joseph Mulinare, a CDC epidemiologist who was the study’s lead author.

He noted that in 1998, the Food and Drug Administration began requiring that folic acid be added to breads, cereals and other products that use enriched flour. Whole-grain breads were not under that mandate because they already contain some folate.

Low-carb diets increased in popularity during the early 2000s. Women who avoided flour and bread products because of their carbohydrates may have also taken in less folic acid, Mulinare said.