| Matchup | Time | TV |
| No. 1 Ohio State at No. 13 Iowa |
| Pick: Ohio State 28-17 | 5p | ABC |
| No. 3 USC at Washington State |
| Pick: USC 37-14. | 4p | TBS |
| Alabama at No. 5 Florida |
| Pick: Florida 24-14. | 12:30p | CBS |
| No. 6 Michigan at Minnesota |
| Pick: Michigan 36-13 | 5p | ESPN |
| Sam Houston State at No. 7 Texas |
| Pick: Texas 55-0 | 4p | |
| Mississippi State at No. 9 LSU |
| Pick: LSU 45-10 | 9:30a | |
| No. 10 Georgia at Mississippi |
| Pick: Georgia 33-13 | 6p | |
| No. 24 Ga. Tech at No. 11 Va. Tech |
| Pick: Virginia Tech 23-20 | 12:30p | |
| Purdue at No. 12 Notre Dame |
| Pick: Notre Dame 47-31 | 11:30a | NBC |
| No. 14 Oregon at Arizona State |
| Pick: Oregon 33-27 | 12:30p | ABC |
| No. 15 Tennessee at Memphis |
| Pick: Tennessee 38-14 | 9a | |
| Louisiana Tech at No. 18 Clemson |
| Pick: Clemson 51-16 | 4p | |
| No. 20 California at Oregon State |
| Pick: California 40-20 | 1:05p | |
| Kansas at No. 21 Nebraska |
| Pick: Nebraska 40-15 | 4p | |
| No. 22 Boise State (plus 4) at Utah |
| Pick: Utah 28-27 | Noon | Versus |
| Colorado at No. 25 Missouri |
| Pick: Missouri 24-12 | 9:30a | FSN |
